NCT03154242Unknown不适用
Effect of Genetic Polymorphisms on Clinical Outcome of Platinum Based Chemotherapy in Non-Small Cell Lung Cancer Patients
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Progression-free survival (PFS)
研究概览
简要总结
This Study evaluate the effect of Polymorphism in the Excision repair cross-complementing group 5 (ERCC5) (rs1047768 and rs751402) gene on the clinical outcome of Platinum-based regimens used in the treatment of Non-Small Cell Lung Cancer (NSCLC) patients
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newly diagnosed with immunohistochemically and pathologically confirmed non-small cell lung cancer (NSCLC).
- •Eastern Cooperative Oncology Group performance status (ECOG PS) = 0-
- •Chemotherapy naïve.
- •Age >18 years.
- •Adequate bone marrow reserve
排除标准
- •Presence of Central nervous system(CNS) metastases.
- •Inadequate liver function
- •Inadequate renal function
- •Serious comorbid systemic disorder incompatible with the study.
结局指标
主要结局
Progression-free survival (PFS)
时间窗: From the date of starting the chemotherapy until the date of documented disease progression or date of death from any cause assessed up to 12 months
It's defined as the time from day 1 of chemotherapy to the day of documented disease progression or death from any cause.
次要结局
未报告次要终点
研究者
Esraa Salah Abdal Hay Abdal Khalek
demonstrator of clinical pharmacy
Ain Shams University
研究点 (1)
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