Prognostic Value of Non-invasive Index of Endothelial Function in Emergency Department Patients With Undifferentiated Chest Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 503
- 试验地点
- 2
- 主要终点
- Prognostic performance of Endo-PAT in predincting major adverse cardiovascular events
研究概览
简要总结
The objective of this study is to determine the prognostic performance of endothelial function assessment, using endothelial peripheral arterial tonometry (Endo-PAT), associated to TIMI risk score, in patients consulting the emergency department for non-traumatic chest pain.
To determine the sensitivity, specificity, negative and positive predictive value of this method that was not previously used for this purpose.
详细描述
Chest pain is a frequent reason for consultation in the emergency room, which can be as much as 5 to 10% of consultants. Stratifying the cardiovascular risk for patients consulting for chest pain is sometimes difficult.
The endothelium plays a crucial role in maintaining the tone and vascular integrity and in particular the secretion of vasodilator and vasoconstrictor mediators. In most vascular pathologies, this equilibrium will be broken by the attenuation of the vasodilating function of the endothelium. This is called endothelial dysfunction.
Several tools for measuring endothelial function have been developed, the main characteristics of which are: noninvasive, reproducible, independent operators, predictive of the disease, safe for subjects, inexpensive and easy to use.
In this study we will be interested in digital plethysmography which has shown its effectiveness in:
- Screening for cardiovascular risk in asymptomatic subjects.
- The risk of a new cardiovascular event in the sick.
- Evaluation of the response to certain therapies.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any patient ≥ 25 years consulting for chest pain in the emergency department from 8:00 am to 8:00 pm (for the unavailability of the endopat device during the guard).
排除标准
- •Chest pain of traumatic origin.
- •Hemodynamic instability.
- •Myocardial infarction requiring urgent revascularization.
- •Parkinsonism: tremor problem.
- •Refusal, communication problem.
结局指标
主要结局
Prognostic performance of Endo-PAT in predincting major adverse cardiovascular events
时间窗: 30 days
To determine the sensitivity, specificity, negative and positive predictive value of the Endopat associated to TIMI risk score in the the prediction of major adverse cardiovascular events in patients consulting the emergency department for chest pain
次要结局
未报告次要终点
研究者
Pr. Semir Nouira
Professor
University of Monastir