NCT01586299Unknown不适用
The Role of Non Steroidal Anti Inflammatory Drugs in the Treatment of Pleuropneumonia in Children. a Randomized Controlled Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- clinical improvement as manifested by resolution of fever and length of hospital admission.
研究概览
简要总结
The purpose of this study is to evaluate the influence of routine NSAIDs treatment for hospitalized children with pleuropneumonia in comparison with acetominophen treatment (all in conjunction with adequate antibiotic therapy).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age less than 18 years
- •admission in Schneider childrenMC of Israel, wards a/c
- •clinical diagnosis of pneumonia with evidence of pleural effusion on chest X-ray
- •parental informed consent
- •follow-up ability after discharge
排除标准
- •pneumonia secondary to foreign body aspiration
- •immune deficiency
- •chronic lung disease other than asthma (CF, CLD of prematurity, Familial Dysautonomia, etc)
- •significant premorbidity (organ failure, rheumatic disease, etc)
- •endotracheal/endobronchial devices including tracheostomy.
- •parental refusal to participate in the study.
研究组 & 干预措施
ibuprofen
Experimental
干预措施: Ibuprofen (Drug)
acetaminophen
Active Comparator
干预措施: Acetaminophen (Drug)
结局指标
主要结局
clinical improvement as manifested by resolution of fever and length of hospital admission.
时间窗: participants will be followed for the duration of hospital stay, an expected average of 10 days
次要结局
- clinical improvement as manifested by respiratory parameters (tachypnea, dyspnea, Fio2),and inflammatory markers.(participants will be followed for the duration of hospital stay, an expected average of 10 days)
研究者
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Risk of Acute Kidney Injury in Patients With Heart FailureHeart FailureNCT02642081National Taiwan University Hospital100
已完成
不适用
Use of Non Steroidal Antiinflammatory Drugs in Patients With Community Acquired PneumoniaCommunity-acquired PneumoniaNCT02523885Hôpital Louis Mourier181
已完成
不适用
Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye DiseaseModerate to Severe Dry Eye SyndromeNCT01562795Wenzhou Medical University48
已完成
不适用
Influence of Non-steroidal Anti-inflammatory Drugs (NSAID) on Muscle RegenerationMuscle DamageNCT00832663Bispebjerg Hospital32
进行中（未招募）
1 期
Impact of prescribing nonsteroidal anti-inflammatory drugs in pleurodesis surgery after pneumothorax: a prospective randomized controlled double-blind multicenter noninferiority studyCTIS2024-511226-32-00Centre Hospitalier Universitaire Amiens Picardie358