Interaction of Potassium Measures With Potassium Channel Genetic Variants on Diabetes Risk: The Atherosclerosis Risk in Communities (ARIC) Study and Jackson Heart Study (JHS)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11,812
- 主要终点
- Associations of serum potassium and KCNJ11 variants with incident diabetes as represented by odds ratio
研究概览
简要总结
The investigators propose to study the association of the KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11) polymorphisms on diabetes risk in the Atherosclerosis Risk in Communities (ARIC) and Jackson Heart Study (JHS) cohorts. The investigators also propose to test for an interaction between serum K and these genetic variants. By testing for such an interaction, it will be determined if, among participants with these genetic variants, a low-normal serum K was a stronger predictor of diabetes risk compared to those participants without these genetic variants.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Member of the Atherosclerosis Risk in Communities (ARIC) Study or Jackson Heart Study (JHS) cohorts
排除标准
- •Had not fasted 8 or more hours for the baseline visit
- •Prevalent diabetes at baseline exam
- •Missing information on serum potassium
- •Missing single nucleotide polymorphism (SNP) data
- •Evidence of kidney dysfunction
- •Race other than black/African American or white/Caucasian
- •Missing other covariates
结局指标
主要结局
Associations of serum potassium and KCNJ11 variants with incident diabetes as represented by odds ratio
时间窗: through study completion, mean of 8 years of follow-up
Calculation of odds ratio will be used to represent the risk of incident diabetes associated with serum K, rs5215, and rs5219 within the cohort
次要结局
未报告次要终点