The Effects of Glycogen Availability on the Skeletal Muscle Molecular Response After Concurrent Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Proteins involved in hypertrophy
研究概览
简要总结
This is a randomized, counterbalanced crossover design, in which 14 male subjects will complete two experimental trials. Each trial will be separated by a minimum of at least 12 days (range: 12-30 days). The study aims to investigate the effects of low glycogen availability on skeletal muscle molecular response after a concurrent exercise day.
详细描述
Two experimental exercise trials; a low carbohydrate (= LOW) and a high carbohydrate (= HIGH) trial. During both experimental days subjects will complete an continues submaximal cycling bout in the morning followed by a resistance exercise session in the early afternoon. During the LOW trial subjects will receive a low carbohydrate mixed meal, during the HIGH trial subjects will be provided with a high carbohydrate meal. In addition, on both experimental days subjects will receive adequate protein beverages. Lastly, protein will be provided post resistance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male gender between 18 and 30 years of age
- •BMI between 18.5 - 25 kg/m2
- •Participating in regular exercise training (at least 1 exercise session, and a maximum of 3 exercise session per week)
- •Used to different types of exercise (endurance, resistance and/or concurrent)
- •Willing to give blood samples
- •Willing to give muscle biopsies
- •No use of antibiotics during the study or in the past month
- •No drug use
- •Suitable veins for blood withdrawal
- •Registered by a general-practitioner
- •Consumption of alcohol beverages is less than 21 per week
- •No blood donor during the study
- •No vegetarian and willing to eat meat during the experimental days
- •Able to be present and participate at both test days and pre testing moments
- •Not employed, or intern, or working on thesis at the department of Human Nutrition at Wageningen University
- •Not participating in another scientific study (except EetMeetWeet)
- •Able to participate during the experimental days en pre tests
- •Able to speak Dutch
排除标准
- •Medical condition that can interfere with the study outcome (i.e. cardiovascular disease, pulmonary disease, gluten intolerance)
- •Systolic blood pressure >160 mmHg and/or diastolic blood pressure >100 mmHg
- •Use of medications known to interfere with gene expression in the muscles (i.e. statins, fenofibrate)
- •Use of antithrombotic therapy (marcoumar, sintromitis).
- •Diagnosed diabetes mellitus type 1 or 2
- •(Chronic) injuries of the locomotor system that can interfere with the intervention
研究组 & 干预措施
Low carbohydrate
Subjects will eat a low carbohydrate diet
干预措施: Standard meal containing low or high carbohydrate content (Other)
High carbohydrate
Subjects will eat a high carbohydrate diet
干预措施: Standard meal containing low or high carbohydrate content (Other)
结局指标
主要结局
Proteins involved in hypertrophy
时间窗: 10 hours
次要结局
未报告次要终点