Application of the Detection of Circulating Tumor Cell and Circulating Tumor DNA in the Diagnosis of Metastasis in Gastric Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Quantity of CTCs
研究概览
简要总结
To investigate the value of CTCs and ctDNA in the diagnosis of metastasis in ascites/peritoneal flushing fluid and blood; To investigate the influence of laparoscopic CO2 pneumoperitoneum establishment on peritoneal and hematogenous metastasis of advanced gastric cancer; To explore the influence of the number and type of CTCs and ctDNA on metastasis and prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who sign informed consent.
- •Gastric cancer is determined by more than 2 pathologists.
- •Patients with Borrmann III/IV gastric cancer.
排除标准
- •Patients who complicate with other malignant tumors.
- •Patients who complicate with other serious heart and lung diseases.
- •Patients who receive preoperative neoadjuvant chemotherapy.
结局指标
主要结局
Quantity of CTCs
时间窗: 1 day
To count the circulating tumor cells in ascites and blood.
Classification of CTCs
时间窗: 1 day
To classify the circulating tumor cells in ascites and blood.
Expression of ctDNA
时间窗: 1 day
To assess the expression of circulating tumor DNA in ascites and blood, including YAP1, LAMC1 and DDIT4.
次要结局
未报告次要终点
研究者
Kai Li
Deputy Director of surgical Oncology
First Hospital of China Medical University