NCT02597179Unknown不适用
Genome Sequencing in Refractory Breast Cancer to Molecular Targeted Therapy and Young Breast Cancer
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- Number of Participants With Mutated Genes and/or Abnormal Gene expression and/or Different Immune signature That Affect to Treatment Outcome.
研究概览
简要总结
The purpose of this study is to investigate and analyse genomic profiles in patient with breast cancer who failed standard treatment, refractory and young breast cancer.
详细描述
The hypothesis is that genomic profiling measured by CancerSCAN, cfDNA, Whole exome sequencing (WES), Whole transcriptome sequencing (WTS), FACS(Fluorescence-Activated Cell Sorting), cytokine and immunologic signature analysis would be helpful to find out tolerance for chemotherapy and innovate new therapeutic strategies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically or cytologically confirmed breast cancer that is either metastatic or young breast cancer(≤ 40 years of age).
- •HER2 positive patient who failed HER2 target therapy including trastuzumab with feasible biopsy site.
- •Triple Negative Breast Cancer patient who failed standard therapy with feasible biopsy site.
- •Hormone Receptor positive patient who failed standard therapy with feasible biopsy site.
- •Age ≥ 21 years
- •Written informed consent
排除标准
- •No feasible biopsy site
- •No written informed consent
结局指标
主要结局
Number of Participants With Mutated Genes and/or Abnormal Gene expression and/or Different Immune signature That Affect to Treatment Outcome.
时间窗: 1 year
次要结局
未报告次要终点
研究者
Young-Hyuck Im
MD, Ph.D, Division of Hematology-Oncology
Samsung Medical Center
研究点 (1)
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