Coronavirus Pediatric Serological Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 49
- 试验地点
- 1
- 主要终点
- SARS-CoV-2 antibody levels in asymptomatic patients
研究概览
简要总结
The Coronavirus Pediatric Serological Study's aim is to provide a better insight of children's immune response after SARS-CoV-2 infection.
Serological tests were conducted on blood samples taken 3 to 5 months after the children's viral infection.
The study was performed in collaboration with the Institute of Medical Immunology, were antibody levels were measured and immunoglobulin subclasses profiles were studied.
详细描述
The hospital laboratory provided us the list of children under 15 years old tested for SARS-CoV-2 in Saint-Pierre Hospital (Brussels) by PCR on nasopharyngeal swab between March 1 2020 and December 31 2020.
The medical files of all children that were tested positive for SARS-CoV-2 were reviewed and clinical information was collected.
For each positive child, the family was contacted by phone 3 months after the proven viral infection in order to ask permission to take a single blood test.
Covid19 serologies were performed in the hospital laboratory, and blood samples were then sent to the Institute of Medical Immunology, were antibody levels and immunoglobulin subclasses were studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Months 至 179 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Tested positive for SARS-CoV-2 by PCR on naso-pharyngeal swab performed in Saint-Pierre Hospital (Brussels) between March 1 2020 and December 31 2020
排除标准
- 未提供
结局指标
主要结局
SARS-CoV-2 antibody levels in asymptomatic patients
时间窗: 3 to 5 months after SARS-CoV-2 infection
Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who did not show any symptoms at the time of the viral infection
SARS-CoV-2 antibody levels in hospitalized patients
时间窗: 3 to 5 months after SARS-CoV-2 infection
Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children who required an hospitalisation at the time of the viral infection
SARS-CoV-2 antibody levels in mildly symptomatic patients
时间窗: 3 to 5 months after SARS-CoV-2 infection
Measurement of SARS-CoV-2 IgG (total and subclasses), IgA (total and subclasses) and IgM levels in the sera of children presenting mild symptoms at the time of the viral infection
次要结局
未报告次要终点
研究者
Lisa Tomasi
Doctor (pediatrician)
Centre Hospitalier Universitaire Saint Pierre