NCT01049646已完成不适用
Interaction of Apelin and Angiotensin in the Systemic Circulation
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Cardiac output
研究概览
简要总结
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
Apelin improves that pumping ability of the heart and we wish to know if this action persists in the presence of increased levels of angiotensin II.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •> 18 years old
- •Healthy volunteers
排除标准
- •Lack of informed consent
- •Age < 18 years,
- •Current involvement in other research studies,
- •Systolic blood pressure >190 mmHg or <100 mmHg
- •Malignant arrhythmias
- •Renal or hepatic failure
- •Haemodynamically significant aortic stenosis
- •Severe or significant co morbidity
- •Women of childbearing potential.
- •Any regular medication
- •Previous history of any cardiovascular disease
研究组 & 干预措施
Angiotensin II
Active Comparator
干预措施: Angiotensin II (Drug)
Saline infusion
Placebo Comparator
干预措施: Saline (Drug)
结局指标
主要结局
Cardiac output
时间窗: 90 mins
次要结局
- Systemic haemodynamics(90mins)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Interaction of Apelin and Angiotensin in the Human Forearm CirculationHeart DiseaseVasodilationNCT00901888University of Edinburgh12
已完成
不适用
Interaction of Apelin and Angiotensin in the Human Forearm CirculationHeart DiseaseVasodilationNCT00901745University of Edinburgh12
已完成
不适用
Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin UpregulationHeart DiseaseVasodilatationHeart FailureNCT00901719University of Edinburgh12
已完成
不适用
Investigating the Inotropic Potential of ApelinHeart FailureNCT01179061University of Edinburgh24
已完成
不适用
Association Between Some Polymorphisms in Apelin/ Apelin Receptor Genes and Coronary Artery Disease in Syrian PatientsHypertensionCoronary Artery DiseaseNCT05562687Damascus University223