Processed Residual Pump Blood in Cardiac Surgery: The PRBC Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- the proportion of patients transfused with homologous red blood cells (RBC)
研究概览
简要总结
The study is an randomized controlled trial (RCT) of 198 coronary artery bypass graft (CABG) patients, exploring whether ultrafiltration of residual blood in the cardiopulmonary bypass circuit reduces transfusion and bleeding.
详细描述
Blood products are a limited resource and cardiac surgery is a high consumer. Processing residual cardiopulmonary bypass (CPB) volume via ultrafiltration may improve hemostasis and reduce transfusion through clearing activated complement, activated coagulation components, and proinflammatory cytokines. Unlike cell saver technology, ultrafiltration has the advantage of maintaining plasma proteins, platelets, and coagulation factors. We sought to establish if the processing of residual CPB volume with ultrafiltration reduces homologous blood transfusion and bleeding.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •at least 18 years of age
- •were to undergo isolated on-pump CABG
- •were able to give informed consent
排除标准
- •performed autologous blood donation
- •underwent off-pump CABG
- •emergency procedure
- •resternotomy
- •known bleeding disorder not drug related
- •history of heparin-induced thrombocytopenia
- •Jehovah's Witness
- •intra-operative catastrophe prior to randomization
结局指标
主要结局
the proportion of patients transfused with homologous red blood cells (RBC)
时间窗: At 30 days post-operatively
次要结局
- Proportion of patients transfused with any blood product(At 30 days post-operatively)
- Volume of pRBC's transfused post-operative(At 30 days post-operatively)
- Post-operative hemorrhage(At 24 hours post-operative)
- Discharge Hemoglobin(A date of discharge, median 5 days in study)
- Length of hospital stay(From day to surgery to discharge, median 5 days in this study)