Effect of Ventilation on Speed of Induction of Anesthesia in Desflurane, Sevoflurane, and Isoflurane
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 主要终点
- End-tidal concentrations of isoflurane, sevoflurane and desflurane, and BIS values with hypo-, normo-, hyperventilation
研究概览
简要总结
Three groups of patients are going to have minor surgery under general anesthesia with inhaled anesthetics and different ventilatory setting (Tidal volume: 8, 10, 12 ml/kg, respiratory rate: 10/min each). Group A (Sevoflurane) will use sevoflurane, group B (Desflurane) will use desflurane, and group C (Isoflurane) will use isoflurane. It will be observed differences among the groups for ventilatory effects on speed of induction.
Duration of this randomised controlled trial will be about 3 months. Estimated sample size will be 36 patients(12 in each group).
详细描述
No premedicant will be given. The anesthetic workstation and a circulatory circuit will be prefilled with 1.0 MAC of inhaled anesthetic that will be selected randomly.
- Group A (n=12): Sevoflurane 2.0 vol%
- Group B (n=12): Desflurane 6.0 vol%
- Group C (n=12): Isoflurane 1.2 vol%
Each group has 3 subgroups according to the ventilatory setting that will also be randomly determined.
- Hypoventilation: tidal volume 8 ml/kg, respiratory rate 10 /min
- Normoventilation: tidal volume 10 ml/kg, respiratory rate 10 /min
- Hyperventilation: tidal volume 12 ml/kg, respiratory rate 10 /min
Patients will be preoxygenated with 100% oxygen (5 L/min) for 5 minutes under pulse oximeter, EKG, and noninvasive blood pressure monitoring. Bispectral index (BIS) monitor will be applied.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA PS I, II
- •Age: 20-60 years male and female
- •Elective schedule with minor surgery
- •BMI < 30
排除标准
- •Patients with pulmonary, cardiac, endocrinal, neuromuscular and neurological diseases or past history
- •Upper airway anomaly or deformity
- •ASA PS III or higher
- •Pregnant women
- •BMI >= 30
研究组 & 干预措施
Group A(Sevoflurane)
Twelve patients will be enrolled in this group. They will be divided into subgroups with ventilatory settings.
Each subgroup has 4 patients.
A8: tidal volume(8 ml/kg) and respiratory rate(10 /min) A10: tidal volume(10 ml/kg) and respiratory rate(10 /min) A12: tidal volume(12 ml/kg) and respiratory rate(10 /min)
干预措施: Sevoflurane (Drug)
Group B(Desflurane)
Twelve patients will be enrolled in this group. They will be divided into subgroups with ventilatory settings.
Each subgroup has 4 patients.
A8: tidal volume(8 ml/kg) and respiratory rate(10 /min) A10: tidal volume(10 ml/kg) and respiratory rate(10 /min) A12: tidal volume(12 ml/kg) and respiratory rate(10 /min)
干预措施: Desflurane (Drug)
Group C(Isoflurane)
Twelve patients will be enrolled in this group. They will be divided into subgroups with ventilatory settings.
Each subgroup has 4 patients.
A8: tidal volume(8 ml/kg) and respiratory rate(10 /min) A10: tidal volume(10 ml/kg) and respiratory rate(10 /min) A12: tidal volume(12 ml/kg) and respiratory rate(10 /min)
干预措施: Isoflurane (Drug)
结局指标
主要结局
End-tidal concentrations of isoflurane, sevoflurane and desflurane, and BIS values with hypo-, normo-, hyperventilation
时间窗: at 0, 30, 60, 90, 120, 180, 240, 300, 360, 480, 600, 720 sec after volatile gas starts
The inspiratory, and end-tidal concentrations of volatile anesthetics, partial pressure of end-tidal carbon dioxide will be recorded from an S/5 Avance anesthetic workstation (Datex-Ohmeda) and an embedded monitor. BIS values are measured with a BIS monitor.
次要结局
未报告次要终点
研究者
Junyong In
Assistant professor
DongGuk University