The Relationship Between Cardiac Cycle Efficiency and Postoperative Troponin Elevation in Patients Undergoing Pancreatic Surgery.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Spearman correlation between cumulative intraoperative duration of CCE < -0.2 and postoperative hsTnT concentration
研究概览
简要总结
Knowing how intraoperative anesthesia management and cardiac cycle monitoring affect postoperative cardiac outcomes in patients undergoing pancreatic surgery can help develop a protocol for future cases.
Whether cardiac damage following non-cardiac surgery can be prevented and the necessary precautions are not yet clear, and the most important finding when it occurs is elevated troponin levels. This can occur even without ECG changes or chest pain. Prevention could contribute to a reduction in postoperative morbidity and mortality, and a shorter hospital stay.
The primary aim of this study is to evaluate the correlation between the duration of cardiac cycle efficiency remaining below zero and increased troponin levels.
详细描述
In patients undergoing non-cardiac surgery with cardiac risk factors, baseline values for preoperative troponin and pro-BNP are monitored as recommended by guidelines, followed by daily troponin monitoring for at least 3 days. Pancreatic surgeries are classified as high-risk surgeries by relevant guidelines, and cardiac output monitoring is recommended in this patient group with a Class 1A indication and evidence level. In this context, cardiac output monitoring with arterial wave analysis is routinely performed in our clinic, and the relevant parameters are followed. This observational study will examine the correlation between the intraoperative cardiac turnover trend and the highest troponin value within 3 days postoperatively. No specific intervention or protocol will be applied to the patients for this study. Preoperative troponin testing and postoperative troponin monitoring are recommended for patients over 65 years of age undergoing high-risk surgery, and for patients over 45 years of age with cardiac risk factors (history of cerebrovascular events, insulin-dependent diabetes mellitus, history of coronary artery disease, history of heart failure, serum creatinine > 2 mg/dL, high-risk surgery). In general surgery clinics, this monitoring is routinely performed in this patient group, in accordance with the recommendations of relevant guidelines, to reduce perioperative morbidity/mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥65 years, or age ≥45 years with at least one predefined comorbidity. Scheduled to undergo pancreaticoduodenectomy.
- •Presence of at least one of the following comorbidities in patients aged ≥45 years:
- •Diabetes mellitus
- •Hypertension
- •Coronary artery disease
- •Congestive heart failure
- •Moderate-to-severe valvular heart disease
- •Peripheral arterial disease
- •Moderate-to-severe pulmonary hypertension
- •Previous cerebrovascular accident occurring >1 month before surgery
- •Previous pulmonary embolism occurring >1 month before surgery
- •Provision of written informed consent.
排除标准
- •Atrial fibrillation on the day of surgery.
- •Sepsis on the day of surgery.
- •Pulmonary embolism on the day of surgery.
- •Pulmonary embolism within the preceding 1 month.
- •Acute coronary syndrome within the preceding 1 month.
- •Cerebrovascular accident within the preceding 1 month.
- •Preoperative hsTnT >65 ng/L.
- •Glomerular filtration rate <60 mL/min.
- •Newly developed postoperative arrhythmia or embolic event that could influence postoperative hsTnT concentrations.
- •Planned pancreaticoduodenectomy being abandoned after laparotomy.
结局指标
主要结局
Spearman correlation between cumulative intraoperative duration of CCE < -0.2 and postoperative hsTnT concentration
时间窗: From the start of intraoperative hemodynamic monitoring to the first postoperative morning (approximately 24 hours after surgery).
The primary outcome is the Spearman rank correlation coefficient (r\_s) between two measures: (1) cumulative intraoperative duration during which cardiac cycle efficiency (CCE) remains below -0.2, measured in minutes using the MostCare arterial waveform analysis system; and (2) high-sensitivity cardiac troponin T (hsTnT) concentration measured on the first postoperative morning, expressed in ng/L and determined using an electrochemiluminescence immunoassay (Roche Diagnostics). The correlation will quantify the strength and direction of the relationship between cumulative exposure to CCE \< -0.2 and postoperative hsTnT concentration.
次要结局
- Effective Arterial Elastance (Ea)(During surgery.)
- Total Arterial Impedance (Ztot)(During surgery.)
- Cardiac Cycle Efficiency (CCE)(During surgery)
- Stroke Volume (SV)(During surgery)
- Maximal Rate of Pressure Rise (dP/dtmax)(During surgery)
研究者
Taner Abdullah
Assoc. Prof.
Istanbul Saglik Bilimleri University
