The Effect Site Concentration of Remifentanil for Preventing QTc Interval Prolongation During Intubation Under Propofol-remifentanil Anesthesia in Elderly Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The effect site concentration for preventing QTc interval prolongation
研究概览
简要总结
To find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients
详细描述
The increase of Corrected QT (QTc) interval is associated with age. It is known that most inhalation anesthetics or intravenous anesthetics can influence the QTc. In addition, tracheal intubation during induction can stimulates sympathetic activity, which, as a results, prolong the QTc interval. Therefore, the aim of study is to find out the effect site concentration of remifentanil for preventing QTc interval prolongation during intubation under propofol-remifentanil anesthesia in elderly patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 65 years ASA class I-II who received surgery with endotracheal intubation
排除标准
- •emergency surgery
- •electrocardiography abnormality
- •hypertension
- •diabetes mellitus
- •end stage renal disease
- •moderate to severe cardiac disease
- •moderate to severe liver dysfunction
研究组 & 干预措施
Male
To find out the effect site concentration of remifentanil for preventing QTc prolongation < 15 sec during intubation : Dixon's up-and-down method
干预措施: remifentanil (Drug)
Female
To find out the effect site concentration of remifentanil for preventing QTc prolongation < 15 sec during intubation : Dixon's up-and-down method
干预措施: remifentanil (Drug)
结局指标
主要结局
The effect site concentration for preventing QTc interval prolongation
时间窗: 2 min
次要结局
未报告次要终点
研究者
So Yeon Kim
Clinical assistant professor
Severance Hospital