NCT01122160已完成不适用
Gastric pH as a Possible Determinant of Anthocyanin Absorption
USDA Beltsville Human Nutrition Research Center1 个研究点 分布在 1 个国家目标入组 13 人开始时间: 2010年5月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Gastric pH
研究概览
简要总结
Anthocyanins are phytonutrients that provide blue, purple and red colors to fruits and vegetables. The purpose of the study is to determine whether absorption of anthocyanins occurs in the acid pH of the stomach and to determine whether altering stomach pH by use of an over-the-counter medicine, Prilosec TM, alters absorption of anthocyanins from strawberries and blackberries.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 22 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 18.5 kg/m2 to 30 kg/m2
- •Age 22 to 59 years
排除标准
- •Plans to have MRI analysis or other contact with MRI equipment during the study
- •Has implanted or portable electro-mechanical medical device such as a cardiac pacemaker or infusion pump
- •Suspected strictures, fistulas or physiological GI obstruction
- •Allergy to omeprazole
- •Current use of clopidogrel (Plavix) or use within the past 3 months
- •Use of warfarin, prescription antifungals/anti-yeast drugs, diazepam, and digoxin
- •Chronic daily use of nonsteroidal anti-inflammatory drugs (ibuprofen, naproxen, etc.)
- •History of bariatric or other gastric surgery
- •Frequent use of antacids
- •Use of proton pump inhibitors in past 3 months
- •History of acid reflux
- •History of gastrointestinal disorders or gastrointestinal surgery
- •History of bezoars (packed collection of partially digested or undigested material that is unable to exit the stomach)
- •Crohn's disease, diverticulitis or inflammatory bowel disease
- •Inability to swallow large pills
- •Dysphagia (Trouble or pain with swallowing food or pills)
- •Allergy to strawberries or blackberries
- •Pregnant women
- •Lactating women
- •Pregnancy in last 12 months
- •History of kidney disease
- •History of liver disease
- •History of metabolic disorder
- •History of some cancers
- •Tobacco use in past 6 months
- •Use of oral or IV antibiotics in past month
- •Use of herbal supplement in past month
研究组 & 干预措施
placebo
Placebo Comparator
Placebo with berries (blackberries + strawberries)
干预措施: placebo (Drug)
omeprazole
Experimental
Prilosec (omeprazole) 20.6 mg tablet with berries (blackberries + strawberries)
干预措施: omeprazole (Drug)
结局指标
主要结局
Gastric pH
时间窗: 1 hour prior to gastric emptying on Day 7 of the given intervention
次要结局
未报告次要终点
研究者
Janet Novotny
Research Physiologist
USDA Beltsville Human Nutrition Research Center
研究点 (1)
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