Short-term effects on blood pressure of reducing nitrate metabolism using antibacterial mouthwash in treated hypertensive individuals

The University of Western Australia0 个研究点目标入组 25 人开始时间: 2013年4月15日最近更新: 2020年1月13日

适应症

试验速览

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•* Men and women will be aged between 50 and 70 years
•* Regular use of at least one antihypertensive medication for elevated blood pressure
•* Clinic/office systolic blood pressure will be >120 mmHg

•* Use of more than 3 antihypertensive medications
•* A change in antihypertensive medication within the past 1 month
•* Inability to attend clinic/office visits
•* Clinic/office systolic blood pressure greater than 160 mm Hg or less than 120 mm Hg; or diastolic blood pressure greater than 100 mm Hg;
•* Use of antibiotics (within previous 1 months);
•* current or recent (<6 months) smoking;
•* body mass index < 18 or > 35 kg/m2;
•* current cardiovascular or peripheral vascular disease, or diagnosed diabetes, or history of a cardiovascular event;
•* a psychiatric illness, or presence of other major illnesses such as cancer;
•* current or recent (within previous 6 months) significant weight loss or gain (> 6% of body weight);
•* alcohol intake > 210 g per wk for women and > 280 g per wk for men;
•* pregnant or lactating women;
•* inability or unwillingness to consume beverages provided.

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