NCT05884814招募中不适用
Timing of Resistance Exercise, Glucose Control and Exercise Adaptations in People With Type 1 Diabetes: a Randomised-controlled Trial
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Change in muscle strength
研究概览
简要总结
The aims of the current study are
- to compare the effects of acute morning and afternoon resistance exercise on blood glucose levels in people with type 1 diabetes.
- to compare the effects of morning and afternoon resistance exercise training on cardiometabolic health outcomes in people with type 1 diabetes
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Physician confirmed type 1 diabetes for at least 1 year
- •Stable insulin therapy for 3 months prior to the study
排除标准
- •BMI of 45 or higher
- •BP of 160/100mmHg or higher
- •autonomic neuropathy
- •severe proliferative retinopathy
- •joint or limb injuries preventing weight-bearing activity
- •autonomic neuropathy
- •severe proliferative retinopathy
- •any other medical condition that prevents participants from exercising safely.
研究组 & 干预措施
Control
Placebo Comparator
Habitual physical activity
干预措施: Habitual physical activity levels (Behavioral)
Morning exercise
Active Comparator
Exercise training between 6-10am
干预措施: Morning exercise (Behavioral)
Afternoon exercise
Active Comparator
Exercise training between 4-8pm
干预措施: Afternoon exercise (Behavioral)
结局指标
主要结局
Change in muscle strength
时间窗: Change from baseline to 12 weeks
Sum of one repetition maximum for the 7 resistance exercise
Change in interstitial glucose time in range
时间窗: Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session
Interstitial glucose time in range (3.9-10mmol/L) measured via continuous glucose monitoring
次要结局
- Change in interstitial glucose average(Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session)
- Change in appendicular skeletal muscle mass(Change from baseline to 12 weeks)
- Change in whole body fat mass(Change from baseline to 12 weeks)
- Change in interstitial glucose time in hyperglycaemia(Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session)
- Change in HbA1c(Change from baseline to 12 weeks)
- Change in interstitial glucose time in hypoglycaemia(Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session)
- Change in physical function(Change from baseline to 12 weeks)
- Change in interstitial glucose variability(Change from 6 hours before (baseline) to 6 hours after (post-exercise) an exercise training session)
研究者
Dr. Ebaa Al Ozairi
Chief Medical Officer
Dasman Diabetes Institute
研究点 (1)
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