NCT04469543已完成不适用
A Retrospective Cohort Study: Influence of MTHFR C677T and A1298C Polymorphisms on the Survival of Pediatric Patients With Non-Hodgkin's Lymphoma
Sun Yat-sen University1 个研究点 分布在 1 个国家目标入组 374 人开始时间: 2014年1月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 374
- 试验地点
- 1
- 主要终点
- Death
研究概览
简要总结
The primary purpose of this retrospective study was to investigate the influence of methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism on the survival of pediatric patients with Non-Hodgkin lymphoma (NHL) treated with modified NHL-BFM95 protocol in south China.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged ≤ 18 years;
- •newly diagnosed as the four main categories of NHL(Burkitt's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma, and diffuse large B-cell lymphoma) between 2014 and 2020;
- •treated according to the modified BFM95 protocol.
排除标准
- •aged > 18 years;
- •not newly diagnosed as the four main categories of NHL between 2014 and 2020;
- •treated according to chemotherapeutic regimens except for the modified BFM95 protocol.
结局指标
主要结局
Death
时间窗: About six years
Overall survival time was calculated from the time of initial diagnosis to death
Events including progression, relapse, and secondary cancer
时间窗: About six years
Event-free survival (EFS) time was calculated from the time of initial diagnosis to first event.
次要结局
未报告次要终点
研究者
Xiao-Fei Sun
MD
Sun Yat-sen University
研究点 (1)
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