ISRCTN43577261已完成未知
The influence of methylenetetrahydrofolate reductase C677T genotype and folate status on deoxyribonucleic acid methylation and uracil misincorporation in the colon of healthy volunteers
King's College London Nutritional Sciences Research Division0 个研究点目标入组 60 人开始时间: 2006年10月6日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
2013 results in: http://www.ncbi.nlm.nih.gov/pubmed/24108782
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •No lesions detected on full colonoscopy
排除标准
- •1. Colorectal polyps or cancer discovered at present colonoscopy
- •2. Current or previous diagnosis of cancer, or a strong family history of colorectal cancer or adenomatous polyposis coli
- •3. Inflammatory bowel disease
- •4. Current or past history of gluten-sensitive enteropathy
- •5. Clinical and/or laboratory evidence of intestinal malabsorption
- •6. Significant renal or liver disease
- •7. Pregnancy
- •8. Epilepsy
- •9. Alcoholism
- •10. Pernicious anaemia
- •11. Serum vitamin B12 levels less than 180 ng/l and the use of medication known to antagonise the metabolism of folate
研究者
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