Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR
- Conditions
- the Effect of MTHFR C677T on Folate Metabolism
- Interventions
- Dietary Supplement: folic acid plus B6 and B12Dietary Supplement: folic acid
- Registration Number
- NCT01105351
- Lead Sponsor
- Universität des Saarlandes
- Brief Summary
The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. For example, post supplementation differences in (6S)-5-CH3-H4folate between CC and TT are above 30%.
- Detailed Description
The investigators aim to test the effect of low doses of folic acid with or without B6 and B12 on folate forms in relation to polymorphisms in folate catabolising enzymes in elderly people. Our hypothesis is that differences in folate forms after folic acid supplementation might be due to polymorphisms in folate catabolising enzymes. Therefore, folic acid might be retained by people with certain genotypes.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
- Males and females
- Age > 65 years.
- Renal dysfunction
- Recent stroke, or coronary event (within the last 3 months)
- Current cancer treatment
- Antifolate (e.g. methotrexate) treatment
- Ileum resection
- Current B-vitamin supplement
- Epilepsy medications
- Megaloblastic anemia or other indications for treatment with high doses of folate or vitamin B12.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description folic acid plus B6 and B12 folic acid plus B6 and B12 folic 400 µg plus vitamin B12 plus B6 Folic acid folic acid folic acid alone
- Primary Outcome Measures
Name Time Method blood metabolic markers 18 months we will measure primary folate forms after folic acid supplement
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Saarland
🇩🇪Homburg, Saarland, Germany