Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma. Asplit Face Dermoscopic and Clinical Study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 25
- 主要终点
- Efficacy and safety of fractional CO2 laser in treatment of melasma.
研究概览
简要总结
The aim of the study:
1.To compare the efficacy and safety of fractional CO2 laser in combination with vitamin c and tranexamic acid in the treatment of melasma.
2 .To assess the value of dermoscope in measuring of the response to treatment in melasma patients compared to clinical scoring.
详细描述
Melasma is a chronic dermatologic condition defined by hyperpigmented macules and patches that appear in areas of sun exposure .
Traditionally, the mainstays of treatment for melasma have been topical bleaching agents and strict photoprotection.
Additional adjuvant treatment modalities include chemical peels, dermabrasion, and laser treatments, all of which have demonstrated limited efficacy. There has been an interest in studying the effects of vitamin c and tranexamic acid in melasma.
The development of fractional resurfacing has led to improvements to melasma treatment with decreased incidence of post-inflammatory hyperpigmentation; these improvements are due to the enhanced healing times and decreased inflammation as a result of the formation of microscopic columns of tissue destruction.
These microscopic columns of damaged tissue are surrounded by areas of normal tissue, allowing for shorter migratory paths for the healing keratinocytes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All types of melasma (epidermal, dermal, and mixed) will be included .
- •Patients older than 19 years of age.
排除标准
- •Pregnancy, breastfeeding.
- •Patients taking drugs that induce facial pigmentation e.g, oral contraceptive pills, or hormonal replacement therapy at the time of the study or during the past 12 months.
- •Patients using of any topical bleaching within 1 month before recruitment.
- •Employment of chemical peels or laser therapy during the past 6 months.
- •Concomitant use of anticoagulants, bleeding disorders.
研究组 & 干预措施
Patients with all types of melasma
Fractional ablative CO2 laser : For each patient, Right side of the face : Fractional ablative CO2 laser will be followed by immediate topical application of vitamin c 3% .
Left side of the face: Fractional ablative CO2 laser will be followed by immediate topical application of tranexamic acid.
- Fractional ablative CO2 laser sessions will be performed using the following parameters: power 8-10 W(according to the skin type), spacing 1000 μm (5.3% density), dwell time 400 μs, and stack .
- During the session, protective goggles will be used both by the patient and by the physician.
干预措施: Fractional co2 laser (Device)
结局指标
主要结局
Efficacy and safety of fractional CO2 laser in treatment of melasma.
时间窗: 1year
1.: For each patient, Right side of the face : Fractional ablative CO2 laser will be followed by immediate topical application of vitamin c 3% . Left side of the face: Fractional ablative CO2 laser will be followed by immediate topical application of tranexamic acid. * Fractional ablative CO2 laser sessions will be performed using the following parameters: power 8-10 W (according to the skin type), spacing 1000 μm (5.3% density), dwell time 400 μs, and stack . * During the session, protective goggles will be used both by the patient and by the physician. acid in the treatment of melasma. 2 .To assess the value of dermoscope in measuring of the response to treatment in melasma patients compared to clinical scoring.
次要结局
未报告次要终点
研究者
Khadija Qenawi
Doctor
Assiut University