Effect of Minimally Processed Animal Protein on Biomarkers for Cognitive Decline
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Concentration of phosphatidylcholine in blood
研究概览
简要总结
Minimally processed animal protein is a premier source of essential macro and micronutrients in the diet and is important, especially to older adults who are at increased risk of nutritional deficiency and age-related physiological changes. Our central hypothesis is that adding lean animal protein within a healthy diet following macronutrient recommendations for Americans will enhance nutrient adequacy and attenuate markers of cognitive decline. This is a retrospective study leveraging samples collected from the feeding trial NCT05581953. PI for both studies are the same.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Generally, good health status based on one routine physical in the past 15 months, current health status
- •Normal HbA1C, weigh 110 lb or more
- •Age 65 years or more, generally healthy, all races and both sexes
- •Generally practicing a meat-based dietary pattern, do not have any special dietary requirements, and
- •Willingness to comply with the study protocol, including on-site meal consumption and sample/data collection.
排除标准
- •Medication usage, probiotic, long-term antibiotic, and tobacco/drug/alcohol use
- •Not on any special diet within 3 months of recruitment, and do not intend to lose weight
- •Impaired kidney functions
- •Active history of cancer, diabetes, heart, liver, and kidney diseases
- •Major gastrointestinal disorders in the past 3 months
- •History of heart attacks or stroke
- •Unable to meet in-person visit requirements for dining, picking up meals, and tests
- •Any mental health condition affecting the ability to provide written informed consent
- •If they had not had a routine health checkup 12 months before recruitment.
- •If they were unwilling to abstain from taking nutritional supplements, alcohol, non-study foods, and beverages during the study period.
研究组 & 干预措施
Test
Low UPF with Red meat
干预措施: Red meat-based meal (Other)
Test
Low UPF with Red meat
干预措施: No meat diet (Other)
Control
Low UPF no meat
干预措施: Red meat-based meal (Other)
Control
Low UPF no meat
干预措施: No meat diet (Other)
结局指标
主要结局
Concentration of phosphatidylcholine in blood
时间窗: 8 weeks
Using Microplate Assay
次要结局
未报告次要终点
研究者
Moul Dey
Professor
South Dakota State University