Effects of Hookah Smoking on Vascular Regulation: Novel Insight Into Endothelial Function
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 58
- 试验地点
- 2
- 主要终点
- Brachial artery flow-mediated dilation
研究概览
简要总结
The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.
详细描述
The investigators will measure acute endothelial and vascular changes before and after a 30-minute Hookah smoking session in a controlled laboratory environment to: (1) Determine the acute effects of Hookah smoking on large-vessel endothelial vasodilator function measured by brachial artery flow mediated dilation; (2) Determine the acute effects of Hookah smoking on micro-vessel endothelial function as measured by reactive hyperemia peripheral arterial tonometry; (3) Determine the acute effects of Hookah smoking on pulse wave velocity and aortic pressure waveform measured by pulse tonometry.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 29 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 29 years of age
- •Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12 months
- •Have not smoked cigarettes within the past 12 months
排除标准
- •History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease
- •Exhaled carbon monoxide level >10 ppm
- •BP < 140/90 mmHg
- •BMI <18.5 or > 30 kg•m2
- •Resting heart rate > 100 beats/min
- •Taking prescription medication
- •History of illicit drug use
结局指标
主要结局
Brachial artery flow-mediated dilation
时间窗: change from baseline to immediately after smoking
次要结局
- Reactive hyperemia peripheral arterial tonometry(change from baseline to immediately after smoking)
研究者
Florian Rader
M.D, M.Sc.
Cedars-Sinai Medical Center