The Effects of Non -Surgical Periodontal Therapy on Glycemic Control and Periodontal Health in Diabetic Patients With Periodontitis (Randomized Controlled Clinical Trial)
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 44
- 主要终点
- glycosylated haemoglobin (HbA1c)
研究概览
简要总结
Is the non-surgical periodontal therapy can improve glycemic control in type 2 diabetic patients with chronic periodontitis?
详细描述
The aim of the present study was to monitor the clinical outcomes and the metabolic response of non-surgical periodontal therapy in patients with chronic periodontitis and uncontrolled type 2 diabetes.
Regarding clinical and metabolic parameters at baseline, no differences were displayed between two groups. However, at 3-months follow-up period the patients within a test group were demonstrated better clinical outcomes than patients in a control group
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of diabetes type 2 for more than five years Type 2 diabetes with HbA1c level from 7% to 9% at the last medical evaluation Diagnosis with chronic periodontitis
排除标准
- •Alcoholism and smoking
- •Presence of any systemic disorders other than hypertension and diabetes
- •Diabetic major complications
研究组 & 干预措施
control group
no intervention during study period
test group
Metronidazole 400mg,three times daily for two weeks
Amoxicillin 500mg,three times daily for two weeks.
干预措施: amoxicillin 500mg and metronidazole 400mg (Combination Product)
结局指标
主要结局
glycosylated haemoglobin (HbA1c)
时间窗: 3 months
Blood was taken from a peripheral vein to monitor HbA1c using high-performance liquid chromatography
次要结局
未报告次要终点
研究者
Yasser El Makaky
Associated professor
Taibah University