The Effect of Non-surgical Periodontal Therapy on Serum Resistin Level in Chronic Periodontitis Patients With or Without Type 2 Diabetes Mellitus
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cairo University
- Enrollment
- 30
- Locations
- 2
- Primary Endpoint
- serum resistin
Study Overview
Brief Summary
non-surgical periodontal debridement was performed for diabetic patients with chronic periodontitis as well as for non-diabetic patients but also with chronic periodontitis. Serum resistin level was assessed in the two groups before and after periodontal therapy and also was compared to a healthy control group.
Detailed Description
Background: Resisitin is a recognized marker for chronic inflammatory conditions that could be directly linked with type 2 diabetes mellitus. The aim of this study was to assess serum resistin level in type 2 diabetic patients with chronic periodontitis.
Methods: Forty individuals were recruited in this study and were divided into three groups, diabetic group consisted of 15 diabetic patients (type 2 diabetes mellitus) with moderate to severe chronic periodontitis, non-diabetic group consisted of 15 non-diabetic patients with moderate to severe chronic periodontitis and healthy group consisted of 10 non-diabetic individuals with healthy periodontium. Non-surgical periodontal therapy with supra and subgingival debridement was performed for the diabetic and non-diabetic groups. Pocket depth, clinical attachment level, plaque index, gingival index, serum Resistin and high sensitivity C-Reactive Protein assay were recorded for both groups before and after treatment, while HbA1c was recorded for the diabetic group.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 40 Years to 55 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •diagnosed with moderate to severe chronic periodontitis.
- •Presence of a minimum of 15 natural teeth
- •Presence of at least four teeth with one or more sites with probing pocket depth (PPD) ≥5mm and clinical attachment level (CAL) ≥4mm
- •agreement to participate in the study and sign a written informed consent
Exclusion Criteria
- •Patients who received any periodontal treatment or professional scaling and root planing of the teeth for at least 6 months prior to the study initiation
- •A history of antibiotics therapy and anti-inflammatory drugs within the previous 6 months
- •Pregnancy or use of contraceptives or any medication related to diabetes
- •former or current smokers ˂ 5 years.
Outcomes
Primary Outcomes
serum resistin
Time Frame: 3 months
ng/ml
Secondary Outcomes
- probing pocket depth(3 months)
- C-reactive protein(3 months)
- clinical attachment loss(3 months)
Investigators
Weam Ahmed Elbattawy
Dr. Principal Investigator
Cairo University