Use Dual-energy X-ray Absorptiometry and Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- change in bone mineral density
研究概览
简要总结
The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •severe knee osteoarthritis
- •post menopausal women
排除标准
- •immune disease
- •end stage of renal disease who receive dialysis
- •history of fracture at ipsilateral distal femur
结局指标
主要结局
change in bone mineral density
时间窗: before the surgery and after the sugery (6month ,12month)
Use dual energy x-ray absorptiometry to detect to BMD at the distal femur
次要结局
未报告次要终点
研究者
National Taiwan University Hospital
Use dual-energy x-ray absorptiometry and quantative microradiography to predict the periprosthetic bone loss in distal femur after total knee arthroplasty
National Taiwan University Hospital