The Significances of Intact Vagal Innervation for the Glucose and GLP1 Induced Insulin Secretion
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- insulin secretion
研究概览
简要总结
The aim of this study is to investigate the role of transmission via the vagal nerve for the effect of glucose and Glucagon-like peptide-1 (GLP-1) in respect to insulin secretion.
The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with and without intact nervous supply.
详细描述
GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by dipeptidyl peptidase IV so only 10-15% enters the systemic circulation. This has led to the hypothesis that GLP-1 interact locally with afferent sensory nerve fibers. We investigated the role of intact vagal innervations on the effect of glucose and GLP-1 on the insulin secretion
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •normal fasting plasma glucose
- •normal hemoglobin
- •informed consent
排除标准
- •type 1 diabetes mellitus or type 2 diabetes mellitus
- •body mass index > 30
- •inflammatory bowel disease
- •intestinal surgery
- •serum creatinine > 250 µM and/or albuminuria
- •ALAT > 2 x normal value
- •Severe cardiac insufficiency
- •in treatment with medicine which cannot be paused for 12 hours
研究组 & 干预措施
Vago
Truncally vagotomized subjects (due to duodenal ulcer operation)
干预措施: Dipeptidyl peptidase 4 (DPP 4) inhibitor (Drug)
Vago
Truncally vagotomized subjects (due to duodenal ulcer operation)
干预措施: oral glucose (Other)
Cardia
Truncally vagotomized subjects (due to cardia resection)
干预措施: Dipeptidyl peptidase 4 (DPP 4) inhibitor (Drug)
Cardia
Truncally vagotomized subjects (due to cardia resection)
干预措施: oral glucose (Other)
Ctrl
Healthy matched control subjects
干预措施: Dipeptidyl peptidase 4 (DPP 4) inhibitor (Drug)
Ctrl
Healthy matched control subjects
干预措施: oral glucose (Other)
结局指标
主要结局
insulin secretion
时间窗: four hours
The insulin secretion during a four-hour oral glucose tolerance test (OGTT) and an intravenous isoglycaemic clamp is evaluated
次要结局
- plasma GLP-1(12 time points within four hours)
- plasma GIP(12 time points within four hours)
- plasma glucagon(12 time points within four hours)
- plasma GLP-2(12 time points within four hours)
- plasma PYY(12 time points within four hours)
研究者
Jonatan I Bagger
MD
University Hospital, Gentofte, Copenhagen