Respiratory Muscle Dysfunction in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Markers for inflammation
研究概览
简要总结
Respiratory muscle dysfunction in critically ill patients is associated with elevated morbidity, including prolonged weaning from mechanical ventilation. The causes for respiratory muscle dysfunction in these patients is poorly understood and no effective treatment is available.
The general hypothesis of the present study is that in critically ill mechanically ventilated subjects respiratory muscle dysfunctions results from loss of myosin induced by activation of proteolytic cascades.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severe sepsis / septic shock
- •Clinical reason for laparotomy
- •> 18 years
排除标准
- •No informed consent
- •Medical history of myopathy
- •Unintended weight loss before ICU admission
- •Pregnancy
- •Chronic use of corticosteroids
结局指标
主要结局
Markers for inflammation
时间窗: 1 day
Inflammatory mediators are measured in plasma and diaphragm at the moment the diaphragm biopsy is obtained.
Markers for activation of proteolytic pathway in the diaphragm
时间窗: 1 day
Biochemical analysis is targeted towards activation of several proteolytic pathways (proteasome, lysosmal).
Diaphragm muscle myosin content
时间窗: 1 day
次要结局
- length of ICU stay(6 months)
- Length of mechanical ventilation(6 months)
研究者
Leo Heunks
MD
University Medical Center Nijmegen