A Randomized Comparative Clinical Study to evaluate the effect of Kataka Beeja Churna and Gokshura Churna in the management of Mutrashmari with special reference to Renal Calculi
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- 1)Pain
研究概览
简要总结
Ashmari is one of the disorders of Mutravaha Srotas and it is included in Astamahagada.
The word ‘Ashma’ means ‘stone’ and ‘Ari’ means ‘enemy’. The formation of stone which cause great pain and suffering to the body like an enemy is called Ashmari.
Renal Calculi are one of the most painful and common disorders of urinary tract, which are solid crystals that form from dissolved minerals in urine, caused by both environmental and metabolic problems.
Acharya Sushruta explains Lakshanas of Ashmari as pain in Nabhi (umbilical), Basti (bladder), Sevani (perinealraphe), and Mehana (penis), Mutradharana (obstruction in flow of urine), Sarudhiramutra (haematuria), Mutravikirana (scattering of urine), Gomedakaprakasha (passing of urine like Gomeda), Sasikata (with gravels) and Visrujati (turbid).
The lifetime risk of kidney stone is estimated to be between 5% and 10% with reoccurrence rate as high as 50%.Renal calculi occurs in people of all parts of the world with lower time risk of 3-15% in the west 25% in Asia and 20% in India. Renal calculi are quite common and usually affects people who are between 20-60 years of age, they affect male more than female. It is estimated that renal colic affects about 10-20% of male and 3-5% female.
In India, Kidney stone Disease is prevalent, with an expectancy of 12% in total population reported to be prone to urinary stone. Of this 12%, 50% of the population is affected by renal damage, which even leads to a loss of kidneys.
Acharya Sushruta has described various medicines and surgery. Medical treatment has been advised to be undertaken in the early stage of the disease. Indication for the surgical management has mentioned along with the note of caution regarding complication.
In the context of Ashmari Chikitsa, Acharya Sushruta has advised that surgery to be undertaken only on failure of conservative treatment and when death becomes inevitable if not treated surgically.
Acharya Sushruta explained the use of Gokshura with Madhu and Aviksheera as Anupana in Ashmari Chikitsa.Gokshura has properties like Ashmarihara and Basti Shodana.
Kataka explained in Dhanvantari Nighantu Chandanadi Varga is taken for the study. Acharya while explaining the properties of Kataka states, it is Vaariprasadana, Chedaniya Vishagna and Muootrashmarihara. By going through the individual Guna Karma of Kataka it is said to be Tridoshahara.
The study will be carried out to evaluate the effect of Kataka Beeja Churna and Gokshura Churna in Mutrashmari.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 20.00 Year(s) 至 60.00 Year(s)(—)
- 性别
- All
入选标准
- •Patients between age group of 20-60 years of either sex.
- •Diagnosed patients of Mutrashmari presenting with signs and symptoms of Mutrashmari(renal calculi).
- •Symptomatic and asymptomatic Patients with renal calculi of size 3mm to 10mm in kidney as reported by USG Abdomen and Pelvis.
排除标准
- •Patient suffering with systemic disorders like Ischemic Heart Disease, tuberculosis, diabetes mellitus, hypertension etc 2)Impacted stone.
- •Pregnant and lactating women.
结局指标
主要结局
1)Pain
时间窗: 4 weeks
2)Tenderness over renal angle
时间窗: 4 weeks
3)Dysuria
时间窗: 4 weeks
4)Size of Renal calculi
时间窗: 4 weeks
次要结局
- 1)Hematuria(2)Pyuria)
