TCTR20220423002
已完成
4 期
Effectiveness of 0.3% Hyaluronic Acid Eye Drops in the Treatment of Benign Essential Blepharospasm and Hemifacial Spasm
Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.0 个研究点目标入组 47 人2022年4月23日
概览
- 阶段
- 4 期
- 干预措施
- 未指定
- 疾病 / 适应症
- patients with benign essential blepharospasm (BEB) or hemifacial spasm (HFS) during concurrent treatment with botulinum toxin type A (BoNT-A) injection
- 发起方
- Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
- 入组人数
- 47
- 状态
- 已完成
- 最后更新
- 去年
概览
简要总结
After 3 months of treatment with 0.3% HA eye drops, patients with BEB and HSF experienced significant improvements in spasm score (p 0.030, p 0.013), TBUT (p 0.001, p 0.010), and mean corneal fluorescein staining grade (p 0.005, p 0.020). They also reported a significant improvement in the mean subjective dry eye symptom questionnaire score (p 0.010, p 0.007). All parameters in no intervention arm were not significantly changed.
研究者
入排标准
入选标准
- •All patients with the diagnosis of BEB or HFS who were concurrently treated with BoNT\-A injections, regardless of dry eye symptoms, and willing to enroll in the study.
排除标准
- •1\. neurological abnormalities other than craniocervical dystonia
- •2\. features suggestive of secondary dystonias
- •3\. history of other active ocular surface disorders or anterior segment diseases
- •4\. ocular trauma or eyelid/ocular surgery in the preceding 6 months
- •5\. contact lens wear
- •6\. concurrent application of any type(s) of artificial tears or other treatments for DED in the preceding 3 months.
结局指标
主要结局
未指定
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