Hypophosphatemia Deleteriously Affects Outcome of Septic Shock Patients Admitted to ICU
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 317
- 试验地点
- 1
- 主要终点
- The 28-day ICU mortality rate (28-MR)
研究概览
简要总结
Patients with severe sepsis/septic shock complicated by hypophosphatemia are at high risk of developing morbidities other than that underlying sepsis and more vulnerable to higher mortality rate. Thus, the current study hypothesized that diagnosis and management of hypophosphatemia may be advantageous for reduction of morbidity and mortality rates of septic patients admitted to ICU
详细描述
The current study was started since June 2018 till Jan 2020 after approval of the study protocol by the Local Ethical Committee. The study intended to include all patients admitted to ICU with or developed severe sepsis or septic shock within 24-hr after admission to ICU.
All patients admitted to ICU were eligible to evaluation for demographic and clinical data including hemodynamic data. Disease severity and its impact on body organs were evaluated using acute physiology and chronic health evaluation II score (APACHE II) (20) and SOFA (18) scores. Exclusion criteria included maintenance on immunodepressent therapy for any indication, severe hemorrhagic shock, pregnancy and refusal of nearest relative to sign the written concept for study participation. Children and adulthoods younger than 18 years and patients who were expected to die were also excluded from the study.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients admitted to ICU were eligible to evaluation for demographic and clinical data including hemodynamic data.
- •Disease severity and its impact on body organs were evaluated using acute physiology and chronic health evaluation II score (APACHE II) (20) and SOFA (18) scores.
排除标准
- •Maintenance on immunodepressent therapy.
- •Severe hemorrhagic shock.
- •Pregnancy
- •Refusal of nearest relative to sign the written concept for study participation.
结局指标
主要结局
The 28-day ICU mortality rate (28-MR)
时间窗: 28 days
次要结局
- The correlation between 28-MR and incidence of additional morbidities and severity of HP.(28 days)
- The incidence of additional morbidities.(30 days)
研究者
Ayman Anis Metry
Assistant professor
Ain Shams University