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临床试验/NCT06539923
NCT06539923已完成不适用

Sarcopenic Index and Related Factors in Patients With Type 2 Diabetes Applying to Tertiary Health Care Services

Goztepe Prof Dr Suleyman Yalcın City Hospital1 个研究点 分布在 1 个国家目标入组 839 人开始时间: 2024年7月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
839
试验地点
1
主要终点
diabetes duration

研究概览

简要总结

Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is particularly common in individuals with T2DM and is often associated with insulin resistance, chronic inflammation and oxidative stress. The Sarcopenia Index (SI), calculated as serum creatinine divided by serum cystatin C, is a practical tool for assessing sarcopenia and is used in many clinical settings. In this study, we aimed to investigate the relationship between sarcopenic index and variables such as age, diabetes duration, diabetes control and complication-related parameters such as NT-proBNP and Fib4 score in patients with type 2 diabetes.

详细描述

This study was planned retrospectively. Between September 01, 2023 and March 31, 2024, the records of patients who presented to the Diabetes Outpatient Clinic of Goztepe Prof. Dr. Suleyman Yalcin City Hospital for Internal Medicine and whose routine biochemical tests (including NT-proBNP and cystatin C) were found in the system will be retrospectively reviewed. Both male and female patients with a definite diagnosis of type 2 diabetes were included in the study. Inclusion criteria included: age 40 years or older, age 85 years or younger, no acute infection, no steroid use, no acute changes in creatinine or cystatin C levels, no recent surgery, no limb loss. Demographic data included age, gender, duration of diabetes, medications and concomitant diseases. The Fib 4 score was calculated using the patients' routine biochemical and hematologic results. The sarcopenia index was calculated from the serum creatinine/cystatin C values. A cut-off value of 0.90 is normally used for the diagnosis of sarcopenia in people without diabetes, but there is no cut-off value for patients with diabetes. Therefore, in addition to the correlation, the SI value was divided into 3 groups and the patients in the lowest and highest groups were compared with each other.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
40 Years 至 85 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • type 2 diabetes diagnosis
  • with complete biochemical data on record

排除标准

  • acute infection,
  • steroid use,
  • acute changes in creatinine or cystatin C levels,
  • recent surgery,
  • limb loss.

结局指标

主要结局

diabetes duration

时间窗: baseline

relationship between sarcopenic index and diabetes duration

Age

时间窗: baseline

relationship between sarcopenic index and age

Glycemic control

时间窗: baseline

relationship between sarcopenic index and glycemic control using HbA1c levels

FIB4 score

时间窗: baseline

relationship between sarcopenic index and Fib4 score ( reflecting hepatic fibrosis risk)

NT-proBNP

时间窗: baseline

relationship between sarcopenic index and NT-proBNP (NT terminal pro-brain natriuretic peptide-use for assessing heart failure) levels

次要结局

未报告次要终点

研究者

发起方
Goztepe Prof Dr Suleyman Yalcın City Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Ayse N Erbakan

Principal İnvestigator

Goztepe Prof Dr Suleyman Yalcın City Hospital

研究点 (1)

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