Characteristics of Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Continuous glucose profiles of mean data of 24-hour continuous glucose monitoring by the CGMS Gold
研究概览
简要总结
Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects with normal glucose tolerance or impaired glucose regulation. People with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome are at risk of impaired glucose metabolism. Glycemic variability is poorly studied in the nondiabetic individuals. The aim of the study is to investigate the characteristics of glucose fluctuations in the newly diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome individuals.
详细描述
Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects with normal glucose tolerance or impaired glucose regulation. Compared with traditional monitoring methods, continuous glucose monitoring system(CGMS) techniques provides a much more detailed understanding of shifting blood glucose levels throughout the day.It is considered reliable to evaluate glucose variability not only in patients with diabetes but also in nondiabetic individuals.
People with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome are at risk of impaired glucose metabolism and developing diabetes mellitus.Some researchers have shown that 15-30% Growth Hormone-Secreting Pituitary Adenoma are suffering from diabetes, 15-36% impaired glucose regulation. The rate of Cushing Syndrome individuals is 10-30% and 40-45% separately.
Glycemic variability is poorly studied in the nondiabetic individuals and has not been studied in the newly diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome individuals. In this study CGM was used to dynamically monitor patients being newly diagnosed with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- ••newly diagnosed GH-releasing pituitary adenoma
- ••newly diagnosed Cushing Syndrome
排除标准
- ••history of diabetes mellitus and being treated with drugs
- ••being treated with drugs which affect glucose metabolism in the lately 3 months
- ••with other hormones affecting glucose metabolism secreted abnormally by pituitary
- ••serious comorbidity like malignant tumour, severe hepatosis or nephropathy, serious hypertension(blood pressure> 180/110mmhg)
- ••pregnant or breastfeeding women
- ••patients allergic to patches or metal
结局指标
主要结局
Continuous glucose profiles of mean data of 24-hour continuous glucose monitoring by the CGMS Gold
时间窗: 3 days
The monitoring results consisted of one curve and 5 parameters
次要结局
- The correlation of MAGE and cortison in newly diagnosed Cushing Syndrome patients(6 months)
- The correlation of MAGE and IGF-1 in newly diagnosed GH adenoma patients(6 months)
- The mean amplitude of glycemic excursion of newly diagnosed GH adenoma patients(3 days)
- The mean amplitude of glycemic excursion of newly diagnosed Cushing Syndrome patients during the 3 days monitored by CGMS Gold(3 days)
研究者
xiaolong zhao
Principal Investigator, Clinical Associate Professor of Endocrinology department
Huashan Hospital