Impulsivity, a risk factor in relapse to substance use disorder: investigating neural substrates before and after pharmacological challenges

ZonMw0 个研究点开始时间: 2008年9月25日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•·Male, age 18-60 years;
•·For the alcohol dependent group: current DSM-IV diagnosis of alcohol dependence, but recently detoxified and abstinent and not using benzodiazepines for at least one week;
•·For the cocaine dependent group: current DSM-IV diagnosis of cocaine dependence, but recently detoxified and abstinent;
•·For the healthy control group: matched on gender, ethnicity, age and education to the alcohol and cocaine dependent groups.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•·Current use of prescription or illicit psychoactive drugs;
•·Lifetime history of head injury with loss of consciousness for more than 5 minutes;
•·Serious neurological or psychiatric disorders (e.g. psychosis, dementia, bipolar disorder)
•.People with depressive symptoms will be excluded.
•·More than 100 lifetime uses of any class of drug of abuse other than alcohol (alcohol group) or cocaine (cocaine group);
•·Being on an active low-calorie (<1000 calories/day) diet;
•·Unstable medical illness (e.g. hypertension, diabetes, myocardial infarct);
•·Colour blindness;
•·Currently dependent on cocaine for the alcohol dependent group and alcohol for the cocaine dependent group.
•·Less than a lower level education until age 16;
•·With respect to MRI imaging: claustrophobia; presence of non-removable metal objects, use of psychotropic medication.
•·With respect to the medications: use of medication affecting the central nerve system (such as anti-depressants); hypersensitivity for modafinil or rimonabant; use of medication that increases the amount of rimonabant in the blood; any disease of the gastrointestinal system, liver or kidneys.

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