Pharmacokinetics and pharmacodynamics of Tacrolimus and its metabolites at healthy Korean volunteers; the relationship with the CYP3A4 , CYP3A5, MDR-1 genotypes

Kyungpook National University Hospital0 个研究点目标入组 34 人开始时间: 待定最近更新: 2019年3月11日

适应症

试验速览

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•Healthy Korean male subject aged 20 between 55
•Subject without a problem of medical examination by interview, physical examination, ECG, hematology, clinical chemistry

•The patient with chronic disease(diabetes, liver disease, hypertension, pancreatitis, cancer, chronic renal failure,
•The man with a history of such trauma, cerebrovascular disease, epilepsy or a seizure disorder
•The man with a history of Alcoholism, drug abuse and psychopathy
•The associated disease patient who are receiving administration of biological control agents, cytotoxic agents, systemic corticosteroids
•The man with decreased heart function, heart failure, chest pain, myocardial disabilities
•The man with bacterial, viral or serious fungal, protozoal infections
•The man is exceed the limit values set out in the KNUH clinical research centers in the physical examination and clinical pathology
•The man has more than 20% of the standard body weight in Korean characters
•The subject that is not eligible to participate at the discretion of study investigator

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