Outcomes of Sepsis Patients in China: A Registry
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 5,775
- 试验地点
- 1
- 主要终点
- 28-day all-cause mortality
研究概览
简要总结
Sepsis poses a significant public health challenge in China. However, longitudinal real-world evidence on guideline adherence and patient outcomes remains scarce. This registry aims to address these gaps by systematically capturing guideline-concordant treatment patterns and associated outcomes in ICU patients diagnosed according to Sepsis-3.0 criteria across diverse settings, thereby generating actionable evidence to improve the quality of sepsis care nationwide.
详细描述
Sepsis is a major public health challenge in China and remains one of the leading causes of intensive care unit (ICU) admissions, accounting for approximately 20.6% of all ICU cases. However, longitudinal real-world data on adherence to clinical guidelines and associated patient outcomes remain limited. This multicenter observational registry is designed to systematically capture real-world management data from adult ICU patients diagnosed with sepsis according to Sepsis-3.0 criteria. The study will assess current treatment practices and document infection types, anatomical sites, pathogen profiles, and key clinical outcomes. By examining the relationship between treatment patterns and outcomes, this study aims to generate actionable evidence to improve the quality of sepsis care in China. The findings will help identify practice variability, support updates to national guidelines, and promote standardized, evidence-based management across the country.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalized patients aged ≥18 years
- •Sepsis diagnosis meeting Sepsis-3 criteria
- •Informed consent signed by patient or legally authorized representative
排除标准
- •Patients with a prior history of sepsis
- •Sepsis diagnosis >48 hours prior to enrollment
- •Current participation in clinical trial
结局指标
主要结局
28-day all-cause mortality
时间窗: 28 days after enrollment.
次要结局
- ICU mortality(From ICU admission to ICU discharge or death, up to 28 days)
- Ventilator-free days(28 days after enrollment.)
- Rate of compliance with sepsis bundle elements(Patient compliance with sepsis bundles will be assessed within 24 hours after ICU admission.)
研究者
Songqiao Liu
Prof
Southeast University, China
