Characterization of Immune Cell-trophoblast-interaction in Pregnancy Disorders
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,580
- 试验地点
- 1
- 主要终点
- T cell population content at the time of preeclampsia diagnosis compared to controls and verified by flow cytometry
研究概览
简要总结
This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications. In particular, the translation of the uteroplacental syndrome into a maternal syndrome, considered in the multifactorial pregnancy disorder preeclampsia, will be investigated. Immune cell subtypes are causally involved in the formation and translation of preeclampsia by inducing an endothelial dysfunction which leads to cardiovascular damage.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •healthy pregnant women after giving informed consent
- •pregnant with diagnosis of preeclampsia, gestational hypertension or gestational diabetes
排除标准
- •infections
- •alcohol and drug abuse
- •manifest and chronic diseases
结局指标
主要结局
T cell population content at the time of preeclampsia diagnosis compared to controls and verified by flow cytometry
时间窗: at the time of preeclampsia diagnosis compared to controls at the same time point in pregnancy
次要结局
未报告次要终点
研究者
Florian Herse
PhD
Charite University, Berlin, Germany