NCT03943433已完成不适用
The Effect of Oxygen Concentration During Alveolar Recruitment on Absorption Atelectasis
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- Modified lung ultrasound score
研究概览
简要总结
The purpose of this study is to investigate the effect of oxygen concentration during alveolar recruitment on absorption ateletasis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing laparoscopic obstetric or colon surgery with Trendelenburg position
排除标准
- •American Society of Anesthesiologists physical status IV or more
- •Severe cardiovascular disease
- •Severe chronic obstructive pulmonary disease, emphysema
- •History of pneumothorax, bullae
- •History of lung resection surgery
- •Conversion to laparotomy
- •Refusal to participate
研究组 & 干预措施
FiO2_1.0
Active Comparator
Alveolar recruitment is performed with 100% oxygen concentration at specific time points.
干预措施: FiO2_1.0 (Procedure)
FiO2_0.4
Experimental
Alveolar recruitment is performed with 40% oxygen concentration at specific time points.
干预措施: FiO2_0.4 (Procedure)
结局指标
主要结局
Modified lung ultrasound score
时间窗: Intraoperative (at the end of operation, before emergence)
The score is calculated by adding up the 12 individual quadrant scores assessed using lung ultrasound. Each quadrant score ranges from 0 (minimal atelectasis)\~3 (severe atelectasis), so the maximum total score is 36.
次要结局
- Modified lung ultrasound score(Postoperative 30 minutes)
- Intraoperative desaturation(Intraoperative)
- Intraoperative partial pressure of arterial oxygen/fraction of inspired oxygen ratio(Intraoperative (20minutes after each recruitment))
- Postoperative partial pressure of arterial oxygen/fraction of inspired oxygen ratio(Postoperative 30 minutes)
- Postoperative pulmonary complication(Postoperative 24 hours)
研究者
Jae-Hyon Bahk, MD, PhD
Professor
Seoul National University Hospital
研究点 (1)
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