Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 78
- 试验地点
- 1
- 主要终点
- Brain blood flow
研究概览
简要总结
The brain is such a metabolically active organ that it consumes about 20% of oxygen burned every minute by an average adult even though it only contributes about 2% of the body weight. As a result, the brain produces a disproportionately high amount of CO2 every minute in comparison with the rest of the body.
详细描述
The researcher can use Diffuse Optical Spectroscopy Imaging, cerebral non-invasive oximetry instrument, to determine cerebrovascular reactivity during surgery procedure. Specifically, the cerebral tissue O2 saturation can measure by Diffuse Optical Spectroscopy Imaging can use for cerebral blood flow in the evaluation of cerebrovascular reactivity.
Adequate brain perfusion is critical not only to supply oxygen and nutrients but also to wash out metabolic end products including CO2. Blood flow depends on perfusion pressure and vascular bed resistance. It is well known that multiple physiological and pathological factors affect cerebral vasculature, and the resistance to blood flow. The cerebrovascular responsiveness to those factors determines how well the brain can maintain and adjust its perfusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or Female 20 years of age and older
- •Female non-pregnant
- •Subject scheduled for elective surgery under general anesthesia with intubation.
- •Subject who is able to give informed consent.
排除标准
- •Less than 20 years old of age
- •Pregnant woman
- •Subjects currently diagnosed with severe hypertension, myocardial ischemic disease, symptomatic valvular disease(s), symptomatic arrhythmia, uncompensated congestive heart failure, intracranial aneurysm.
结局指标
主要结局
Brain blood flow
时间窗: 6 hours
Optical Imaging assess of Brain blood flow during surgical procedure
次要结局
未报告次要终点
研究者
Beckman Laser Institute and Medical Center
Lingzhong Meng, M.D.,Assistant Clinical Professor and Director of Neuroanesthesia
University of California, Irvine