Tight Glycemic Control and Sepsis Related Dyslipidemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 69
- 主要终点
- establish a relationship between lipid metabolism alterations and glycemic control
研究概览
简要总结
Study of the lipid metabolism under glycemic control in septic patients who got an university 14 bed ICU.
Hypothesis: establish a relationship between lipid metabolism alterations and glycemic control or infusion of exogenous insulin
详细描述
The investigators enrolled 69 consecutive patients with severe sepsis or septic shock and divided them in two different groups after randomization with sealed envelopes.
One group called intensive glycemic control with glycemic levels been between 80 to 110 mg/dl with exogenous insulin.
The other group called conventional glycemic control with glycemic levels been between 180 and 220 mg/dl.
Blood samples were collected at 0, 12, 24, 48 and 72 hours to measure HDL, LDL, Total cholesterol, free fatty acids and oxidized LDL.
Clinical data as creatinine, P/F ratio, bilirubins, platelets, lactate, arterial blood gasometry were either monitored.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients aged between 18 and 80 years old
- •with the diagnostic of septic shock or severe sepsis
排除标准
- •pregnants,
- •previous diagnosis of any cancer,
- •diagnosis of leptospirosis,
- •diagnosis of aids.
结局指标
主要结局
establish a relationship between lipid metabolism alterations and glycemic control
时间窗: 2 years
次要结局
未报告次要终点