NCT05765786招募中不适用
Do we Miss a Common Subset of Primary Aldosteronism in Which There is Cyclical or Exaggerated Diurnal Variation in Secretion?
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Sensitivity and specificity of 24 hour urine tetrahydroaldosterone excretion.
研究概览
简要总结
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
详细描述
The main questions it aims to answer are:
- Can we diagnose more people if we used 24 hour urine measurements?
- In those with high amounts of aldosterone in their urine, is there a variable pattern to their aldosterone production?
Participants will have a 24 hour urine measurement. They will also have multiple blood tests throughout the day to study the variability in aldosterone secretion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity <0.5 nmol/h/L or renin mass <5 ng/L), plasma sodium > 140mmol/L or plasma potassium < 4mmol/L.
- •Patients who have been diagnosed with PA and had previous aldosterone samples <277 pmol/L, a level which would normally not qualify for confirmatory testing.
- •Patients with aldosterone results done at different times that indicate variability in production.
- •Willing to consent and participate in the study.
排除标准
- •Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks.
- •People on end of life treatment.
结局指标
主要结局
Sensitivity and specificity of 24 hour urine tetrahydroaldosterone excretion.
时间窗: 12 months
Can measurement of 24 hour urine tetrahydroaldosterone excretion detect more people with PA than current conventional screening tests?
次要结局
- Differences in timed day and night urine THA measurements.(12 months)
- Variation in aldosterone secretion from day series in those with positive 24h urine THA and those with negative 24h urine THA.(12 months)
- Complete biochemical cure of PA in this cohort of patients that qualify for adrenalectomy.(12 months)
- Complete or partial clinical cure rate of this cohort of patients that qualify for adrenalectomy(12 months)
研究者
研究点 (1)
Loading locations...
相似试验
招募中
不适用
Simplification of Oral Sodium Loading Test in the Diagnosis of Primary Aldosteronism: 2-day Replacing 3-day MethodPrimary AldosteronismNCT06750172Peking Union Medical College Hospital33
招募中
不适用
Primary Aldosteronism in Western NorwayHyperaldosteronismNCT02832388Haukeland University Hospital300
招募中
不适用
Overnight Dexamethasone in Primary Aldosteronism ScreeningPrimary AldosteronismHypertensionNCT06740838Medical University of Gdansk240
招募中
不适用
Prevalence of Primary Aldosteronism in Atrial FibrillationAtrial FibrillationPrimary AldosteronismNCT05973604Aristotle University Of Thessaloniki120
Unknown
不适用
Diagnosis of Primary Aldosteronism: Comparison of Post Captopril Active Renin Concentration and Plasma Renin ActivityPrimary AldosteronismNCT00917345National Taiwan University Hospital150