Diagnostic and Prognostic Roles of Procalcitonin and Highly Sensitive C-Reactive Protein in Early Detection of Burn Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Measurement of c-reactive protein level
研究概览
简要总结
This study aimed to evaluate the value of procalcitonin and highly sensitive c-reactive protein as biomarkers for early detection of sepsis in patients with major burns.
详细描述
Severe burn injuries can cause a marked inflammatory stress response. As the inflammatory state progresses, pro-inflammatory cytokines are continuously released.
C reactive protein (CRP) is closely related to the systemic inflammation in its acute phase, as CRP binds to the damaged cell membranes that associates burn injuries and contributes to the associated inflammatory response.
Procalcitonin (PCT) a precursor protein for calcitonin, which is synthesized by thyroid C-cells, is yet another biomarker valuable in the sepsis diagnosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 3 years to 65 years.
- •Both sexes.
- •Patients with major burn (2nd and 3rd degrees of burn).
排除标准
- •Patients with unrealistic expectations.
- •Patients with inhalational burn injury.
- •Patients with uncompensated chronic disease e.g. hepatic, renal.
- •Patients with mental or psychological troubles affecting the study
结局指标
主要结局
Measurement of c-reactive protein level
时间窗: 5 days of burn injury
Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.
次要结局
- Measurement of procalcitonin level(5 days of burn injury)
研究者
Riwina Adel
Assistant Lecturer of Plastic, Reconstructive and Burn Surgery Center, Faculty of Medicine, Mansoura University, Egypt
Mansoura University