The Role of Histamine in Muscle Protein Synthesis Following Chronic Resistance Training
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Muscle volume
研究概览
简要总结
Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-45 years
- •Not to medium physically active
排除标准
- •Chronic disease
- •High blood pressure
- •Supplement or medication intake
- •Seasonal allergies
- •Vegetarian / vegan
- •Resistance trained
研究组 & 干预措施
1: Placebo
Lactose
干预措施: Placebo (Drug)
1: Placebo
Lactose
干预措施: Resistance training (Behavioral)
H1 blockade: Telfast (180mg Fexofenadine)
H1: Telfast (180mg Fexofenadine)
干预措施: Resistance training (Behavioral)
结局指标
主要结局
Muscle volume
时间窗: Before and after the 10 weeks of resistance training
Change in muscle volume
Maximal dynamic strength of leg press, bench press, bicep curl and leg curl
时间窗: Before and after the 10 weeks of resistance training
Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl
Muscle fiber hypertrophy in muscle biopsies
时间窗: Before and after the 10 weeks of resistance training
Change in muscle fiber hypertrophy in muscle biopsies
Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)
时间窗: Before and after the 10 weeks of resistance training
Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)
Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)
时间窗: Before and after the 10 weeks of resistance training
Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)
次要结局
- Blood pressure (systolic and diastolic)(Before and after the 10 weeks of resistance training)
- Resting heart rate(Before and after the 10 weeks of resistance training)