Clinical Efficacy of Isobaric Ropivacaine 0.75%,4ml Alone and with Dexmedetomidine in Spinal Anaesthesia for Abdominal Hysterectomy: A Prospective Randomised Double Blind Study

Ropivacaine, first levo-isomer an amide local anaesthetic shares many physiochemical properties with bupivacaine but has shown a better safety profile over bupivacaine due to the reduced central nervous system and cardiac toxicity.(5,6) Recent clinical data have shown that ropivacaine is clinically effective and safe for regional anaesthetic techniques with good tolerability. Ropivacaine has been successfully used in spinal anaesthesia for caesarean section, urological surgery, and lower limb orthopedic surgery. However there is scarcity of data in which ropivacaine has been used in SAB for abdominal hysterectomy in which there is more extensive surgery, needing more relaxation than above mentioned surgeries. This prompted us to plan present study.When dexmedetomidine added to intrathecal ropivacaine better clinical profile was noted as compared to ropivacaine alone. However, no study comparing efficacy of ropivacaine 4ml of 0.75% versus ropivacaine 0.75% plus 5µg dexmetomedine in spinal anesthesia has been conducted to date.

 Therefore we are planning present study using 4 ml of 0.75% ropivacaine alone and with 5µg dexmedetomidine   in spinal anesthesia for abdominal hysterectomy, to study sensory and motor block characteristics, success rate, postoperative analgesia, haemodynamic profile, and complications.

Patients who will fulfill inclusion criteria will be enrolled in the study prior to enrolment written and informed consent will be taken. these patients will be randomly divided into two groups of 45 patients in each group using sealed envelope technique:

•   Group R: Patients will receive 4ml (30mg) of 0.75% Isobaric Ropivacaine hydrochloride.

•   Group RD: Patients will receive 4ml (30mg) of 0.75% Isobaric Ropivacaine with 5µg dexmedetomidine hydrochloride (0.05ml)