Local Infiltration Analgesia With Ropivacaine, Ketorolac and Epinephrine Intra- and Postoperatively in Total Knee Arthroplasty
Overview
- Phase
- N/A
- Intervention
- ropivacaine, ketorolac and epinephrine
- Conditions
- Postoperative Pain
- Sponsor
- Region Örebro County
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- Morphine consumption
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
The primary aim of this study is to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect morphine consumption. Secondary end-points are hospital stay, pain intensity and side effects. In an attempt to assess the safety of this technique, knee function and patient satisfaction scores are assessed up to 3 months after surgery.
Detailed Description
Postoperative pain is often severe following knee arthroplasty. Recently, a local infiltration analgesia (LIA) technique was developed by Drs Kerr and Kohan in Sydney, Australia. With this LIA-technique, a long-acting local anesthetic (ropivacaine), a nonsteroidal anti-inflammatory drug (ketorolac), and epinephrine are infiltrated intraoperatively and via an intraarticular catheter postoperatively. We ahve completed a study on unicompartmental knee arthroplasty and the present study is investigating total knee arthroplasties. The primary aim of this study is to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect morphine consumption. Secondary end-points are hospital stay, pain intensity and side effects. In an attempt to assess the safety of this technique, knee function and patient satisfaction scores are assessed up to 3 months after surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for total knee arthroplasty
- •Aged 20-85 yrs
- •ASA physical status I-III and mobility indicating normal postoperative mobilization
Exclusion Criteria
- •Known allergy or intolerance to one of the study drugs
- •Serious liver-, heart- or renal decease
- •Rheumatoid arthritis
- •Chronic pain or bleeding disorder
Arms & Interventions
1 Group A(Active)
Group A (Active) receives a multimodal injection intra- and postoperatively
Intervention: ropivacaine, ketorolac and epinephrine
2 Group P (Placebo)
Group P (Placebo) receives no injection intraoperatively and a saline injection postoperatively
Intervention: saline
Outcomes
Primary Outcomes
Morphine consumption
Time Frame: 0-48 hours
Secondary Outcomes
- hospital stay, pain intensity, side effects, knee function and patient satisfaction scores(0-3 months)