Local Infiltration Analgesia Following Total Knee Arthroplasty
- Conditions
- Postoperative Pain
- Interventions
- Drug: saline
- Registration Number
- NCT00799175
- Lead Sponsor
- Region Örebro County
- Brief Summary
The primary aim of this study is to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect morphine consumption. Secondary end-points are hospital stay, pain intensity and side effects. In an attempt to assess the safety of this technique, knee function and patient satisfaction scores are assessed up to 3 months after surgery.
- Detailed Description
Postoperative pain is often severe following knee arthroplasty. Recently, a local infiltration analgesia (LIA) technique was developed by Drs Kerr and Kohan in Sydney, Australia. With this LIA-technique, a long-acting local anesthetic (ropivacaine), a nonsteroidal anti-inflammatory drug (ketorolac), and epinephrine are infiltrated intraoperatively and via an intraarticular catheter postoperatively. We ahve completed a study on unicompartmental knee arthroplasty and the present study is investigating total knee arthroplasties.
The primary aim of this study is to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect morphine consumption. Secondary end-points are hospital stay, pain intensity and side effects. In an attempt to assess the safety of this technique, knee function and patient satisfaction scores are assessed up to 3 months after surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 48
- Patients scheduled for total knee arthroplasty
- Aged 20-85 yrs
- ASA physical status I-III and mobility indicating normal postoperative mobilization
- Known allergy or intolerance to one of the study drugs
- Serious liver-, heart- or renal decease
- Rheumatoid arthritis
- Chronic pain or bleeding disorder
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Group P (Placebo) saline Group P (Placebo) receives no injection intraoperatively and a saline injection postoperatively 1 Group A(Active) ropivacaine, ketorolac and epinephrine Group A (Active) receives a multimodal injection intra- and postoperatively
- Primary Outcome Measures
Name Time Method Morphine consumption 0-48 hours
- Secondary Outcome Measures
Name Time Method hospital stay, pain intensity, side effects, knee function and patient satisfaction scores 0-3 months
Trial Locations
- Locations (1)
University Hospital Orebro
🇸🇪Orebro, Sweden