Local Infiltration Analgesia (LIA) With Ropivacaine, Ketorolac and Epinephrine Intra- and Postoperatively in Unicompartmental Knee Arthroplasty
Overview
- Phase
- N/A
- Intervention
- ropivacaine, ketorelac and epinephrine
- Conditions
- Postoperative Pain
- Sponsor
- Region Örebro County
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- The primary aim of this study was to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect hospital stay.
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
The primary aim of this study is to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect hospital stay. Secondary end-points are morphine consumption, pain intensity and side effects. In an attempt to assess the safety of this technique, knee function and patient satisfaction scores are assessed up to 6 months after surgery.
Detailed Description
Postoperative pain is often severe following knee arthroplasty. Recently, a local infiltration analgesia (LIA) technique was developed by Drs Kerr and Kohan in Sydney, Australia. With this LIA-technique, a long-acting local anesthetic (ropivacaine), a nonsteroidal anti-inflammatory drug (ketorolac), and epinephrine are infiltrated intraoperatively and via an intraarticular catheter postoperatively. The primary aim of this study is to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect hospital stay. Secondary end-points were morphine consumption, pain intensity and side effects. In an attempt to assess the safety of this technique, knee function and patient satisfaction scores were assessed up to 6 months after surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for unicompartmental knee arthroplasty
- •Aged 20-80 yrs.
- •ASA physical status I-III and mobility indicating normal postoperative mobilization
Exclusion Criteria
- •Known allergy or intolerance to one of the study drugs
- •Serious liver-, heart- or renal decease
- •Rheumatoid arthritis
- •Chronic pain or bleeding disorder
Arms & Interventions
A
Group A (Active) receives a multimodal injection intra- and postoperatively
Intervention: ropivacaine, ketorelac and epinephrine
P
Group P (Placebo) receives no injection intraoperatively and a saline injection postoperatively
Intervention: saline
Outcomes
Primary Outcomes
The primary aim of this study was to evaluate if intra- and postoperative administration of ropivacaine, ketorolac and epinephrine into the operating field would affect hospital stay.
Time Frame: April, 2007
Secondary Outcomes
- Secondary end-points were morphine consumption, pain intensity and side effects. In an attempt to assess the safety of this technique, knee function and patient satisfaction scores were assessed up to 6 months after surgery.(September, 2007)