Local Infiltration Analgesia With Ropivacaine Versus Placebo in Bilateral Knee Arthroplasty
- Conditions
- Postoperative Pain
- Registration Number
- NCT00408707
- Lead Sponsor
- Hvidovre University Hospital
- Brief Summary
The purpose of this study is to examine whether local infiltration analgesia (LIA) with Ropivacaine and adrenaline is effective in the treatment of postoperative pain after total knee arthroplasty.
- Detailed Description
Total knee arthroplasty (TKA) is increasingly common in the treatment of osteoarthrosis. Despite aggressive analgesic regimes, TKA is associated with moderate to severe postoperative pain, delaying mobilization and hospital discharge. A relatively new method for controlling postoperative pain after TKA is local infiltration analgesia (LIA) which consists of local infiltration with Ropivacaine and adrenaline.3 studies haved showed promising results of LIA, but none have documented a superior analgesic effect versus placebo.Patients receiving bilateral knee arthroplasty are recruited to receive LIA and placebo infiltration.The aim of the study is to demonstrate an analgesic effect of LIA versus placebo.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- patients eligible for total knee arthroplasty
- must speak and understand Danish
- must be able to give oral and written consent
- Alcohol or medicine abuse
- Treatment with opioids
- Allergy to local anaesthetics
- Severe obesity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Postoperative pain
- Secondary Outcome Measures
Name Time Method analgésia consumption time to discharge
Trial Locations
- Locations (1)
Hvidovre University Hospital
🇩🇰Hvidovre, Denmark