EEG- or STN LFP-based Neurofeedback Training for Improving Motor Functions in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
- 主要终点
- The feasibility of using EEG-based neurofeedback to help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively.
研究概览
简要总结
The goal of this clinical trial is to test neurofeedback training in both people with Parkinson's disease and healthy control.
The main questions it aims to answer are:
- To demonstrate that EEG based or STN LFP based neurofeedback can help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively;
- To evaluate the learning effect of the neurofeedback training with multiple training sessions
Patient participants will be asked to receive the research intervention called neurofeedback training for maximal three separate sessions. During the intervention, the participants will also be asked to press a pinch meter as fast as possible in order to measure the reaction time, meanwhile, different type of brain signals will be recorded.
. This will be a within-subject cross-over study contrasting the effect of the neurofeedback training and no training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants with symptomatic Parkinson's disease or age-matched healthy control
- •Adequate understanding of verbal explanation or written information given in English
- •Able and willing to give informed consent.
- •Normal or corrected-to-normal vision
排除标准
- •Lack of capacity to consent (judged by the researcher taking consent as not having sufficient mental capacity to understand the study and its requirements)
结局指标
主要结局
The feasibility of using EEG-based neurofeedback to help patients with Parkinson's disease to volitionally modulate pathological brain activities measured non-invasively.
时间窗: 10 days
The final position of the cursor and beta power changes after neurofeedback training will be measured and reported.
Learning effect of the neurofeedback training with multiple training sessions
时间窗: 10 days
The final positions of the cursor and the changes in beta power will be measured and compared across different training sessions.
次要结局
- The effect of EEG-based neurofeedback on motor performance quantified as peak movement velocity in patients with Parkinson's disease(10 days)
- The effect of EEG-based neurofeedback on motor performance quantified as reaction time in patients with Parkinson's disease(10 days)
- The effect of EEG-based neurofeedback on parkinsonian tremor(10 days)
- The effect of EEG-based neurofeedback on motor Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) score(10 days)
- The effect of EEG-based neurofeedback on motor performance quantified as reaction time in healthy age-matched control(10 days)
- The peak movement velocity during the cued motor task will be measured, and compared between training and no-training conditions in healthy age-matched control group.(10 days)