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临床试验/NCT01422668
NCT01422668已完成3 期

Effect of Coffee Consumption on the Glycemic Index of Khalas Dates Tested in Healthy and Diabetic Subjects

United Arab Emirates University1 个研究点 分布在 1 个国家目标入组 23 人开始时间: 2010年3月1日最近更新:
适应症
干预措施

试验速览

阶段
3 期
状态
已完成
入组人数
23
试验地点
1
主要终点
Glycemic Index of Khalas dates with and without coffee

研究概览

简要总结

The aim of this study was to evaluate the composition of Khalas, a very common type of dates used in the UAE and to determine the effects of drinking Arabic coffee on the results of GI tests in both healthy and diabetic subjects.

详细描述

Background:The consumption of dates along with coffee is a deeply rooted habit in many societies. This study was designed to determine the effect of coffee consumption on the glycemic index of a common variety of dates (Khalas) tested in healthy subjects and individuals with type 2 diabetes mellitus.

Methods:Composition analysis was carried out for Khalas dates (Tamer stage) and the weight of the dates flesh equivalent to 50 g of available carbohydrate was calculated. The study subjects were thirteen healthy volunteers with a mean (± SD) age of 40.2 ± 6.7 years and ten participants with type 2 diabetes mellitus (controlled on lifestyle measures and/or metformin) with a mean HbA1c (± SD) of 6.6 ± (0.7 %) and a mean age (± SD) of 40.8 ± 5.7 years. Each subject was tested on five separate days with 50 g of glucose (on 3 occasions) and 50 g equivalent of available carbohydrates from the dates without coffee (on one occasion) and with coffee (on another occasion). Capillary glucose was measured in the healthy subjects at 0, 15, 30, 45, 60, 90 and 120 min and for the diabetics at 0, 30, 60, 90, 120, 150 and 180 min. The glycemic indices were determined as ratios of the incremental areas under the response curves for the dates alone/with coffee compared to glucose. Statistical analyses were performed using Student's t-tests.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Single Group
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •required that those in the healthy group were healthy and in the diabetes group that their diabetes was controlled (HbA1c ≤8%) on diet with or without metformin

排除标准

  • •morbid obesity (BMI > 40 kg/m2)
  • •pre diabetes
  • •pregnancy
  • •presence of gastroenterological disorders
  • •alimentary tract surgery
  • •a history of gastroenteritis in the prior six months
  • •any alcohol intake
  • •taking any medications (except metformin)
  • •poorly controlled diabetes (HbA1c > 8%) and the presence of acute or chronic diseases

研究组 & 干预措施

GI of Khalas dates

Active Comparator

The Glycemic indices of the Khalas dates were measured for healthy and diabetic subjects.

干预措施: Khalas dates (Other)

GI of the Khalas dates with Coffee

Experimental

measuring the effect of 100 ml of coffee consumption on the GI of the Khalas dates among healthy and diabetic subjects.

干预措施: Khalas dates (Other)

结局指标

主要结局

Glycemic Index of Khalas dates with and without coffee

时间窗: 2 or 3 hours

Every subject recieved 50 grams reducing sugars of Khalas dates with and without coffee. Measuring glucose level over 2 hours in Healthy subjects and over 3 hours in diabetic subjects as per a standard protocol.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Juma Alkaabi

Assistant Professor of Medicine, Faculty of Medicine and Health Sciences

United Arab Emirates University

研究点 (1)

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