A Better Understanding of the Association Between Problem Gambling and Psychotic Disorders in Young Adults: a New Path Towards Recovery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 520
- 试验地点
- 2
- 主要终点
- Problem gambling
研究概览
简要总结
The aims of this propsective cohort study are to get a better understanding of the association between problem gambling and psychotic disorders among young adults with first-episode psychosis.
The main questions to be answered are:
- What is the incidence of problem gambling in this population?
- What are the predictors of problem gambling in this population?
To do so, putative predictors of problem gambling will be analyzed using Cox regression models:
- Sociodemographics (e.g., age, gender identity, ethnicity, level of education, employment);
- Psychiatric comorbidities (e.g., substance use disorders, cluster B personality disorders);
- Antipsychotic use (first/second-generation, third-generation [aripiprazole, brexpiprazole, cariprazine]);
- Prior gambling history.
详细描述
All Cox regression models will be adjusted for site-effect. Further multivariable models will be constructed to examine the association between antipsychotic use (as continuous exposure) and incident PBG using the directed acyclic graphs approach to adjust for confounders.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 to 35 years old;
- •Diagnosis of first-episode psychosis (i.e., DSM-5 diagnosis of schizophrenia spectrum and other psychotic disorders, as well as DSM-5 bipolar disorder with psychotic features).
排除标准
- •Active/prior PBG at te time of admission;
- •Loss to follow-up within first three months;
- •DSM-5 diagnosis of psychotic disorder due to a medical condition;
- •Severe intellectual disability.
研究组 & 干预措施
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
干预措施: Antipsychotic use (Drug)
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
干预措施: Psychiatric comorbidities (Other)
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
干预措施: Sociodemographics/socioeconomic status (Other)
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
干预措施: Gambling history (Other)
First-episode psychosis patients
All patients aged 18-35 years with a diagnosis of FEP admitted at two FEP programs in the province of Quebec, Canada.
干预措施: Clinical variables (Other)
结局指标
主要结局
Problem gambling
时间窗: Outcome assessed at every 6-month time point, from patients admission until the first occurrence of the primary outcome, loss to follow-up, or May 1, 2023.
i) Diagnosis of gambling disorder according to DSM-5 criteria, established by the treating psychiatrist, and/or; ii) Problem gambling according to a score of 8 and more on the Problem Gambling Severity Index, as questioned by the clinical case manager and/or treating psychiatrist
次要结局
未报告次要终点
研究者
Olivier Corbeil
PharmD, MSc, Pharmacist, Principal Investigator
Laval University