Metabolomics and Microbiomics in Cardiovascular Diseases
试验速览
- 阶段
- 不适用
- 入组人数
- 750
- 试验地点
- 1
- 主要终点
- Disease-specific metabolic/microbiomic biomarker patterns.
研究概览
简要总结
"MEtabolomics and MicrObiomics in caRdIovAscular diseases Mannheim (MEMORIAM) " is a single-center, prospective and observational study investigating to identify disease-specific metabolic, respectively microbiomic, patterns of patients with high-risk cardiovascular diseases. High-risk cardiovascular diseases comprise patients suffering from acute heart failure (AHF), ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), sepsis, septic shock, ischemic and non-ischemic cardiomyopathy.
详细描述
Scientific evidence about the metabolomic and microbiomic changes in high-risk cardiovascular patients is still lacking.
The acute, critical or progressive disease status predestinies to relevant changes in cardiovascular metobolism. High-risk patients in the present trial comprise those with acute heart failure, myocardial infarction (STEMI and NSTEMI), sepsis, septic shock, ischemic and non-ischemic cardiomyopathy with severely reduced left ventricular ejection fraction (LVEF <35%).
Therfore this study investigates to identify disease-specific patterns of metabolic and microbiomic changes. These patterns may help to understand pathophysiology at the metabolic stages and find out those patients being at highest risk of adverse future outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •above mentioned diseases, diagnosis according to respective guideline
- •written informed consent
排除标准
- •under 18 years
- •rheumatic diseases
- •infections (except septic group)
- •higher grade heart valve diseases
结局指标
主要结局
Disease-specific metabolic/microbiomic biomarker patterns.
时间窗: Within 24h after disease onset
Expression of disease-specific metabolic/microbiomic biomarker patterns at the time of acute disease presentation
次要结局
- All-cause and cardiovascular mortality.(12 months after inclusion)
- Cardiac rehospitalization.(12 months after inclusion)
研究者
Michael Behnes
Attending physician, adjunct professor
Universitätsmedizin Mannheim